Leon Di Stefano

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I am an an applied statistician and Postdoctoral Research Fellow with Prof. Katherine Lee in the Clinical Epidemiology and Biostatistics Unit at the Murdoch Children's Research Institute in Melbourne, Australia.

I work on the design and analysis of adaptive platform trials—clinical trials that investigate multiple interventions for a given disease or condition, with interventions entering or leaving the study as evidence accrues about which ones work best. Specifically I am helping to design an adaptive trial in pediatric sepsis.

Research Interests

I want to help scientists generate clear, comprehensible evidence from biomedical experiments, in particular through

Other interests include graphical causal models; the interplay among evidence (bayesian and likelihood reasoning), robustness (frequentist reliability and model checks), and decision making; and reproducible research using Nix and related technologies.

Background

I completed my PhD in the Department of Biostatistics at the Johns Hopkins Bloomberg School of Public Health, advised by Dr. Kasper Hansen and Prof. Elizabeth Stuart. You can read my dissertation here:

During my doctoral studies I was also part of efforts to pool data from clinical trials of drugs repurposed to treat COVID-19.

Before this I worked in the laboratory of Dr. Tony Papenfuss, and completed undergraduate and masters degrees at the University of Melbourne.

Other Interests

Functional programming, philosophy and theology, classic Hollywood movies, fonts and lettering, spending time with my family.