I am an an applied statistician and Postdoctoral Research Fellow with Prof. Katherine Lee in the Clinical Epidemiology and Biostatistics Unit at the Murdoch Children's Research Institute in Melbourne, Australia.
I work on the design and analysis of adaptive platform trials—clinical trials that investigate multiple interventions for a given disease or condition, with interventions entering or leaving the study as evidence accrues about which ones work best. Specifically I am helping to design an adaptive trial in pediatric sepsis.
Research Interests
I want to help scientists generate clear, comprehensible evidence from biomedical experiments, in particular through
- Designing more efficient clinical trials using bayesian and decision-theoretic approaches.
- Developing methods to complement traditional subgroup analysis for understanding varying treatment effects in clinical trials.
- Developing methods for analyzing high-throughput molecular data.
- Improving statistical communication, including graphics, teaching, and statistical terminology.
Other interests include graphical causal models; the interplay among evidence (bayesian and likelihood reasoning), robustness (frequentist reliability and model checks), and decision making; and reproducible research using Nix and related technologies.
Background
I completed my PhD in the Department of Biostatistics at the Johns Hopkins Bloomberg School of Public Health, advised by Dr. Kasper Hansen and Prof. Elizabeth Stuart. You can read my dissertation here:
- Chapter 2 proposes simple statistics based on order statistics of ranks—we call them rank-gap statistics—for understanding the “overlap” among related conditions based on genomic data.
- Chapter 3 develops the proportional interaction model, a parsimonious nonlinear extension of additive regression adjustment for modelling varying treatment effects in clinical trials and other experiments.
Before this I worked in the laboratory of Dr. Tony Papenfuss, and completed undergraduate and masters degrees at the University of Melbourne.
Other Interests
Functional programming, philosophy and theology, classic Hollywood movies, fonts and lettering, spending time with my family.