I am an applied statistician and Postdoctoral Research Fellow with Prof. Katherine Lee in the Clinical Epidemiology and Biostatistics Unit at the Murdoch Children's Research Institute in Melbourne, Australia. (This is a personal website.)
Research Interests
I work on the design and analysis of adaptive platform trials—clinical trials that investigate multiple interventions for a given disease or condition, with interventions entering or leaving the study as evidence accrues about which ones work best. I am helping to design a platform trial in pediatric sepsis.
More broadly I want to help biomedical scientists generate clear, comprehensible, and decision-relevant evidence from their experiments. I am interested in both clinical trials and laboratory experiments, and in all stages of the process: from planning and design, through modelling and data analysis, to communicating and interpreting results.
Background
I completed my PhD in the Department of Biostatistics at the Johns Hopkins Bloomberg School of Public Health, advised by Dr. Kasper Hansen and Prof. Elizabeth Stuart. There were two projects in my dissertation:
- Chapter 2 proposes simple statistics based on sorted ranks—we call them rank-gap statistics—for understanding the “overlap” among related conditions based on genomic data (R package).
- Chapter 3 studies the proportional interaction model, a parsimonious nonlinear extension of additive regression adjustment for modelling varying treatment effects in clinical trials and other experiments.
Before this I worked in the laboratory of Dr. Tony Papenfuss (primarily in cancer genomics), and completed undergraduate and masters degrees at the University of Melbourne.
Other Interests
Functional programming (including reproducible research using Nix and related technologies), philosophy and theology, classic Hollywood movies, fonts and lettering, spending time with my family.